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Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes - The PROLONG-Steno study
Kasper Olesen1,2, Troels Mygind Jensen1,2, Lars Jorge Diaz1
1Steno Diabetes Center A/S, Gentofte, Denmark.
Insights
Sense of Coherence (SOC) is linked to better health outcomes in type 1 diabetes. Higher SOC was associated with lower LDL cholesterol, suggesting it may be protective against metabolic risk factors.
Area of Science:
- Endocrinology
- Psychology
- Public Health
Background:
- Managing type 1 diabetes (T1D) involves controlling HbA1c, blood pressure, and lipids to prevent complications.
- Sense of Coherence (SOC) is a psychological construct that may influence health behaviors and outcomes.
Purpose of the Study:
- To investigate the association between Sense of Coherence (SOC) and clinical risk factors in individuals with type 1 diabetes.
- To explore the relationship between SOC and biomarkers such as HbA1c, blood pressure, and blood lipids.
Main Methods:
- Data from 125 long-duration type 1 diabetes patients were collected via questionnaires (including SOC) and linked to electronic health records.
- Clinical measures included HbA1c, blood pressure, and lipid profiles (LDL-cholesterol, HDL-cholesterol).
- Statistical analyses, including linear regressions and generalized additive models, were used to examine associations.
Main Results:
- Medium and high SOC levels were significantly associated with lower LDL-cholesterol (p=0.005) in a non-linear manner.
- Low SOC was linked to elevated LDL-cholesterol levels.
- Non-significant trends suggested associations between low SOC and lower HDL-cholesterol and elevated HbA1c.
Conclusions:
- High Sense of Coherence (SOC) may offer a protective effect against elevated LDL-cholesterol in people with type 1 diabetes.
- Interventions aimed at enhancing self-management skills in individuals with low SOC could help prevent metabolic risk factor deterioration.
Aim:
It is a constant challenge for people with type 1 diabetes to maintain appropriate levels of HbA1c, blood pressure and blood lipids in order to prevent or delay deleterious effects of their illness. This study sought to investigate if Sense of Coherence (SOC) is associated with clinical risk factors in people with type 1 diabetes.
Methods:
Questionnaire data, including measure of SOC, was collected from 125 patients with long duration of type 1 diabetes and linked to electronic patient records to obtain clinical measures on HbA1c, blood pressure, and blood lipids. Linear regressions and generalized additive models were applied to explore the associations between SOC and clinical biomarkers.
Results:
Mean age of the participants was 60.7 years (standard deviation = 10.0), 44.0% were men. Medium and high SOC were associated with lower levels of LDL-cholesterol (p = 0.005). This association was non-linear with medium and high levels of SOC being advantageous whereas low SOC was associated with elevated levels of LDL-cholesterol. Moreover, we observed non-significant tendencies to associations between low SOC and low HDL-cholesterol, and elevated HbA1c.
Conclusions:
Findings from this study suggest that high SOC may be protective against elevated LDL-cholesterol among people with type 1 diabetes. Interventions to improve self-management among people with low SOC may prove effective to prevent deterioration of metabolic risk factors.
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