Related Experiment Video
Updated: Jul 27, 2026
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
12.7K
[Embryonal malformation suggests malignant tumor in the tail of the pancreas]
E H Allemeyer1, F Fischer2, B Heitkötter3
1Klinik für Allgemein- und Viszeralchirurgie mit Sektion Proktologie, Raphaelsklinik Münster, Loerstraße 23, 48143, Münster, Deutschland. e.allemeyer@alexianer.de.
Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|October 26, 2017
Abstract
No abstract available in PubMed .
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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...