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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Interplay between TGF-β signaling and receptor tyrosine kinases in tumor development

Qiaoni Shi1, Ye-Guang Chen2

  • 1State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

Science China. Life Sciences
|October 26, 2017
PubMed

Insights

Transforming growth factor-β (TGF-β) signaling and receptor tyrosine kinases (RTKs) pathways interact to drive cancer development. Their crosstalk accelerates tumor growth and metastasis by modulating cell survival and migration.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Cell Signaling

Background:

  • Transforming growth factor-β (TGF-β) signaling is crucial for cell functions and tissue homeostasis.
  • Deregulation of TGF-β signaling is linked to various diseases, notably tumor formation.
  • Receptor tyrosine kinases (RTKs) are key players in tumor development and progression.

Purpose of the Study:

  • To review the intricate interplay between TGF-β signaling and RTK pathways.
  • To elucidate how this crosstalk influences cancer development and metastasis.
  • To summarize current knowledge on their mutual regulation in tumorigenesis.

Main Methods:

  • Literature review of studies investigating TGF-β and RTK signaling in cancer.
  • Analysis of molecular mechanisms underlying the interaction between these pathways.
  • Synthesis of findings on their cooperative roles in tumor progression.

Main Results:

  • TGF-β signaling and RTKs are mutually regulated and interact significantly in cancer.
  • Their interplay modulates cell survival, migration, and epithelial-mesenchymal transition.
  • RTKs can enhance TGF-β's oncogenic activity, while TGF-β can control RTK expression and activity.

Conclusions:

  • The crosstalk between TGF-β signaling and RTKs is a critical determinant of tumor development and metastasis.
  • Understanding this interaction provides insights into potential therapeutic strategies for cancer.
  • Further research into this interplay is essential for advancing cancer treatment.
Keywords:
TGF-βcrosstalkreceptor tyrosine kinasetumor development

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