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Updated: Feb 20, 2026

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A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
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Addiction and Cue-Triggered Decision Processes
B Douglas Bernheim1,2, Antonio Rangel1,2
1Department of Economics, Stanford University, Stanford, CA.
Summary
Addiction may stem from mistaken use, heightened sensitivity to cues, and self-management. This new addiction model integrates psychology, neuroscience, and clinical data for policy insights.
Area of Science:
- Addiction research
- Behavioral science
- Neuroscience of addiction
Background:
- Addiction is often characterized by compulsive substance use despite negative consequences.
- Existing models may not fully capture the subjective experience and self-management aspects of addiction.
Purpose of the Study:
- To propose a novel, tractable model of addiction.
- To explain addiction based on mistaken use, cue sensitization, and self-management.
- To provide a framework for understanding user, substance, and environmental factors in addiction.
Main Methods:
- Synthesizing evidence from psychology, neuroscience, and clinical practice.
- Developing a theoretical model based on three core premises.
- Evaluating the model's ability to map behavior to user, substance, and environment characteristics.
Main Results:
- The proposed model is tractable and generates plausible behavioral mappings.
- The model accounts for key patterns observed in addiction.
- Evidence from multiple disciplines supports the model's premises.
Conclusions:
- The new addiction model offers a coherent framework for understanding the phenomenon.
- The model has implications for developing effective addiction policies and welfare standards.
- Further research can explore the clinical applications of this model.
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