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Antimicrobial polymers offer a new way to fight antibiotic resistance by disrupting bacterial membranes. Highly segmented multiblock copolymers show superior selectivity against specific bacteria, making them promising for infection treatment.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Microbiology

Background:

  • Conventional antibiotics face increasing bacterial resistance.
  • Antimicrobial polymers offer an alternative by disrupting bacterial membranes.
  • Polymer segmentation influences antimicrobial activity and selectivity.

Purpose of the Study:

  • To investigate how polymer segmentation affects antimicrobial selectivity between bacteria and mammalian cells.
  • To synthesize and characterize statistical, diblock, and multiblock copolymers.
  • To evaluate the antimicrobial efficacy and biocompatibility of these polymers.

Main Methods:

  • Synthesis of copolymers using Reversible Addition-Fragmentation chain Transfer (RAFT) polymerization.
  • Analysis of polymer hydrophobicity using High-Performance Liquid Chromatography (HPLC).
  • Antimicrobial testing against *Escherichia coli*, *Pseudomonas aeruginosa*, *Staphylococcus aureus*, and *Staphylococcus epidermidis*.
  • Biocompatibility assessment via hemolysis, erythrocyte aggregation, and mammalian cell viability assays.

Main Results:

  • Segmentation significantly influenced polymer hydrophobicity.
  • Diblock and multiblock copolymers demonstrated superior antimicrobial activity compared to statistical copolymers.
  • Multiblock copolymers exhibited significantly enhanced selectivity for *P. aeruginosa* and *S. epidermidis* at low cationic comonomer content.

Conclusions:

  • Polymer segmentation profoundly impacts physical properties and biological interactions.
  • Multiblock copolymers represent a promising platform for targeted antimicrobial therapies.
  • These materials offer a valuable strategy to combat antimicrobial resistance.