Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

617
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
617
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

589
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
589
Autoimmune Disorders01:29

Autoimmune Disorders

1.9K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.8K
Introduction to Connective Tissues01:11

Introduction to Connective Tissues

16.6K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
16.6K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low serum zonulin level in patients with systemic sclerosis.

Reumatologia·2024
Same author

Professor Witold Eugeniusz Orłowski, a founder of the Polish school of internal medicine: a sesquicentennial remembrance.

Polish archives of internal medicine·2024
Same author

Sleep quality and clinicaland laboratory variables associated with sleep disturbances in patients with systemic sclerosis.

Polish archives of internal medicine·2024
Same author

Correlation between angiotensin-converting-enzyme 2 gene polymorphisms and systemic sclerosis.

Clinical and experimental rheumatology·2023
Same author

A journal as a mirror of continued progress in internal medicine. A century of Polish Archives of Internal Medicine.

Polish archives of internal medicine·2023
Same author

A doctor without boundaries: a memory of Alina Margolis-Edelman on the hundredth anniversary of her birth (1922-2008).

Polish archives of internal medicine·2022

Related Experiment Video

Updated: Feb 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.9K

Systemic sclerosis sine scleroderma.

Eugeniusz J Kucharz1, Magdalena Kopeć-Mędrek1

  • 1Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland.

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis sine scleroderma (ssSSc) is a rare form of systemic sclerosis lacking skin thickening. Early consideration of ssSSc is crucial for diagnosing internal organ fibrotic involvement.

Keywords:
internal organ fibrosissclerodactylysclerodermasystemic sclerosis

More Related Videos

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.3K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.8K

Related Experiment Videos

Last Updated: Feb 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.9K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.3K
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

18.8K

Area of Science:

  • Rheumatology
  • Dermatology
  • Internal Medicine

Background:

  • Systemic sclerosis is a rare connective tissue disease characterized by skin thickening (scleroderma).
  • Systemic sclerosis sine scleroderma (ssSSc) is a rare subset lacking typical skin manifestations but featuring internal organ involvement and serologic abnormalities.
  • ssSSc presents diagnostic challenges due to its subtle or absent cutaneous signs.

Purpose of the Study:

  • To describe the rare subset of systemic sclerosis sine scleroderma (ssSSc).
  • To outline the proposed classification of ssSSc into three types.
  • To emphasize the diagnostic considerations for ssSSc in clinical practice.

Main Methods:

  • Review of existing literature and proposed classification for ssSSc.
  • Analysis of demographic and clinical characteristics of ssSSc patients.
  • Discussion of diagnostic difficulties and clinical implications.

Main Results:

  • ssSSc is characterized by the absence or minimal cutaneous manifestations despite internal organ disease.
  • A three-type classification (complete, incomplete, delayed) for ssSSc has been proposed.
  • ssSSc patients share demographic and clinical similarities with other systemic sclerosis subsets.

Conclusions:

  • Systemic sclerosis sine scleroderma requires high clinical suspicion, especially in cases of unexplained internal organ fibrosis.
  • Recognizing the distinct types of ssSSc aids in diagnosis and management.
  • Further research is needed to fully elucidate the characteristics and optimal management of ssSSc.