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Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis.

Haojun Xie1, Chufang Li, Mincong Zhang

  • 1State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University Academy of Orthopedics of Guangdong Province, Department of Respiratory Disease, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

Medicine
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

The human immunity-related GTPase M (IRGM) gene polymorphisms rs10065172, rs4958842, rs4859843, and rs4859846 are associated with a decreased risk of tuberculosis, particularly in Asian populations. The IRGM rs72553867 polymorphism showed no significant association with tuberculosis risk.

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Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • The human immunity-related GTPase M (IRGM) protein plays a crucial role in cellular autophagy, a key defense mechanism against intracellular pathogens.
  • Previous studies on the association between IRGM gene polymorphisms and tuberculosis (TB) risk have yielded inconsistent findings.
  • Understanding the genetic basis of TB susceptibility is vital for developing targeted prevention and treatment strategies.

Purpose of the Study:

  • To systematically evaluate the association between common IRGM gene polymorphisms (rs10065172, rs4958842, rs4859843, rs4859846, and rs72553867) and the risk of developing tuberculosis.
  • To clarify the conflicting results reported in previous research by conducting a meta-analysis of available case-control studies.
  • To investigate potential population-specific effects, particularly differences between Asian and African/African-American populations.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Embase, and Web of Knowledge databases to identify relevant case-control studies.
  • Data from eligible studies were extracted and pooled to calculate overall odds ratios (ORs) with 95% confidence intervals (CIs) for five specific IRGM polymorphisms.
  • Statistical analyses included heterogeneity assessment (Cochran Q test) and publication bias evaluation (funnel plot, Begg's test, Egger's regression).

Main Results:

  • Nine case-control studies, comprising 3780 TB cases and 4835 controls, were included in the meta-analysis.
  • IRGM polymorphisms rs10065172 and rs4859846 showed a significant association with altered tuberculosis risk across all genetic models.
  • Stratified analyses indicated that rs10065172 conferred a protective effect in Asians but not in African/African-Americans. Significant protective associations were also noted for rs4958842 and rs4859843 in Asians. No significant association was found for rs72553867.

Conclusions:

  • Specific IRGM gene polymorphisms, notably rs10065172, rs4958842, rs4859843, and rs4859846, are significantly associated with tuberculosis risk, particularly demonstrating a protective effect in Asian populations.
  • The findings highlight the potential role of IRGM genetic variations in modulating tuberculosis susceptibility, with notable ethnic differences.
  • IRGM rs72553867 polymorphism is not associated with tuberculosis risk.