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Hypothyroidism as a risk factor for open angle glaucoma: A systematic review and meta-analysis
Shiming Wang1,2, Yue Liu1, Guangying Zheng1
1Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Plos One
|October 26, 2017
Summary
Hypothyroidism is linked to a higher risk of developing primary open-angle glaucoma (POAG). This meta-analysis confirms a significant association, suggesting a need for further research into this connection.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- The association between hypothyroidism and primary open-angle glaucoma (POAG) is a topic of recent scientific interest.
- Previous studies on this relationship have yielded conflicting results.
Purpose of the Study:
- To conduct a meta-analysis to determine the association between hypothyroidism and POAG.
- To synthesize existing evidence regarding the link between hypothyroidism and primary open-angle glaucoma.
Main Methods:
- Literature search conducted across Web of Science, Embase, and PubMed databases.
- Meta-analyses performed using random-effects models.
- Results reported as adjusted odds ratios (ORs) with 95% confidence intervals (CI).
Main Results:
- Eleven studies were included in the final meta-analysis.
- A statistically significant increased risk of POAG prevalence was observed in individuals with hypothyroidism (OR = 1.64, 95% CI = 1.27-2.13).
- Substantial heterogeneity was detected (P < 0.001; I2 = 83.2%); subgroup analysis indicated significant associations in cohort and case-control studies, but not in cross-sectional studies. No significant publication bias was found.
Conclusions:
- Individuals with hypothyroidism demonstrate an elevated risk of developing primary open-angle glaucoma.
- The findings support a significant association between hypothyroidism and increased POAG risk.
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