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Updated: Feb 20, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Qualitative and quantitative analysis of oropharyngeal swallowing in Down syndrome
André Vinicius Marcondes Natel Sales1, Célia Maria Giacheti1, Paula Cristina Cola1,2
1Universidade Estadual Paulista - UNESP - Marília (SP), Brasil.
Purpose:
To describe the qualitative and quantitative temporal analysis of oropharyngeal swallowing in children diagnosed with Down syndrome (DS) through a case series study of six individuals aged 4 to 17 months (mean age = 11.16 months; median = 12 months).
Methods:
Qualitative and quantitative temporal analysis of swallowing using videofluoroscopy and specific software. The following parameters were assessed: presence or absence of oral incoordination, labial sphincter sealing incompetence, oral residue, posterior oral spillage, laryngotracheal penetration and aspiration, pharyngeal and total oral transit time (TOTT).
Results:
Qualitative analysis identified individuals with disorders in at least four of the swallowing parameters investigated. Only one individual presented total oral transit time (TOTT) different from the others. No difference was observed between the cases regarding pharyngeal transit time.
Conclusion:
Qualitative swallowing disorders are observed in children with DS, with difference in TOTT only in the case report of the youngest infant.
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