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Updated: Feb 20, 2026
13:08
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia
Published on: December 2, 2015
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Impaired cortico-limbic functional connectivity in schizophrenia patients during emotion processing
Magali Comte1, Xavier Y Zendjidjian2, Jennifer T Coull3
1Timone Institute of Neuroscience, UMR 7289, CNRS and Aix-Marseille University, Marseille, France.
Social Cognitive and Affective Neuroscience
|October 26, 2017
Summary
Schizophrenia patients show altered brain connectivity, with reduced amygdala interaction during emotional appraisal. Top-down control involves stronger connections, suggesting impaired functional segregation in cognitive brain circuits.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Functional dysconnection is a key feature of schizophrenia.
- Aberrant cortico-limbic circuit interactions may cause emotional processing deficits.
Purpose of the Study:
- Investigate bottom-up appraisal and top-down control in emotion processing.
- Explore cortico-limbic circuit function in schizophrenia using fMRI.
Main Methods:
- Used a functional magnetic resonance imaging (fMRI) paradigm.
- Dissociated ventral automatic and dorsal cognitive circuits.
- Compared schizophrenia patients to healthy controls.
Main Results:
- Schizophrenia patients had reduced amygdala interaction with anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) in bottom-up processing.
- Top-down control showed heightened interactions within and between ACC subregions and with DLPFC.
- Findings suggest impaired functional segregation in the dorsal cognitive circuit.
Conclusions:
- Provides a comprehensive view of cortico-limbic dysfunction in schizophrenia.
- Confirms impaired amygdala-prefrontal cortex information propagation.
- Suggests defective functional segregation in schizophrenia's dorsal cognitive circuitry.
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