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Volume Conduction Coupling of Whisker-Evoked Cortical LFP in the Mouse Olfactory Bulb
1Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.
Abstract:
Local field potentials (LFPs) are an important measure of brain activity and have been used to address various mechanistic and behavioral questions. We revealed a prominent whisker-evoked LFP signal in the olfactory bulb and investigated its physiology. This signal, dependent on barrel cortex activation and highly correlated with its local activity, represented a pure volume conduction signal that was sourced back to the activity in the ventro-lateral orbitofrontal cortex, located a few millimeters away. Thus, we suggest that special care should be taken when acquiring and interpreting LFP data.
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