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The MMP2 rs243865 polymorphism increases the risk of prostate cancer: A meta-analysis

Kun Liu1, Shuo Gu1, Xuzhong Liu1

  • 1Department of Urology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China, 223300.

Oncotarget
|October 27, 2017
PubMed

Insights

The rs243865 single-nucleotide polymorphism in the matrix metalloproteinase 2 gene (MMP2) is linked to an increased risk of prostate cancer. This meta-analysis confirms a significant association between MMP2 rs243865 and higher prostate cancer risk.

Area of Science:

  • Genetics and Oncology
  • Molecular Biology

Background:

  • Prostate cancer is a prevalent malignancy in men globally.
  • The role of specific genetic variations, such as the MMP2 rs243865 polymorphism, in prostate cancer risk requires further clarification.

Purpose of the Study:

  • To investigate the association between the MMP2 rs243865 single-nucleotide polymorphism and prostate cancer risk.
  • To synthesize existing evidence through a meta-analysis.

Main Methods:

  • A systematic literature search was conducted across PubMed, EMBASE, Cochrane Library, CNKI, and WANFANG databases.
  • Data from five studies involving 1895 prostate cancer cases and 1918 controls were extracted and analyzed.
  • Odds ratios (OR) with 95% confidence intervals (95% CIs) were pooled to estimate the association, and study quality and publication bias were assessed.

Main Results:

  • A significant association was found between the MMP2 rs243865 polymorphism and an increased risk of prostate cancer.
  • This association was significant in the co-dominant (CC vs. CT+TT, OR: 1.60), dominant (CC+CT vs. TT, OR: 1.80), and allele (C vs. T, OR: 1.32) models.
  • No significant association was observed in the co-recessive or recessive models.

Conclusions:

  • The MMP2 rs243865 polymorphism is significantly associated with a higher risk of developing prostate cancer.
  • These findings contribute to understanding the genetic predisposition to prostate cancer.
Keywords:
matrix metalloproteinase 2meta-analysispolymorphismprostate cancer

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