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Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism,

Michael J Berridge1

  • 1Laboratory of Molecular Signalling, The Babraham Institute , Cambridge , United Kingdom.

American Journal of Physiology. Cell Physiology
|October 27, 2017
PubMed

Insights

Vitamin D is crucial for development, regulating calcium and redox signaling. Deficiency is linked to infertility and neurodevelopmental disorders, impacting key developmental stages.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Endocrinology

Background:

  • Development relies on intricate signaling systems.
  • Alterations in these pathways cause infertility and neurodevelopmental disorders like ADHD, ASD, and schizophrenia.
  • Calcium signaling is vital from fertilization through organogenesis.

Purpose of the Study:

  • To review the role of vitamin D in regulating developmental signaling pathways.
  • To explore how vitamin D deficiency impacts development.
  • To highlight vitamin D's role in maintaining calcium and redox signaling stability.

Main Methods:

  • Literature review focusing on developmental signaling.
  • Analysis of studies linking vitamin D to developmental processes.
  • Examination of the molecular mechanisms of vitamin D action.

Main Results:

  • Vitamin D is essential for regulating key developmental signaling pathways.
  • Vitamin D deficiency correlates with increased infertility and neurodevelopmental issues.
  • Vitamin D maintains the stability of calcium (Ca2+) and redox signaling.

Conclusions:

  • Vitamin D plays a critical role in ensuring normal development.
  • Maintaining adequate vitamin D levels is important for preventing infertility and neurodevelopmental disorders.
  • Further research into vitamin D's mechanisms can inform therapeutic strategies.
Keywords:
attention deficit hyperactivity disorderautismschizophrenia

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