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Related Experiment Video

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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Identifying motor functional neurological disorder using resting-state functional connectivity.

Jennifer Wegrzyk1, Valeria Kebets2, Jonas Richiardi2

  • 1Department of Clinical Neuroscience, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, Switzerland.

Neuroimage. Clinical
|October 27, 2017
PubMed
Summary

Resting-state functional connectivity (FC) shows promise as a biomarker for motor functional neurological disorder (mFND). This neuroimaging technique can accurately differentiate mFND patients from healthy individuals, aiding in early diagnosis.

Keywords:
BiomarkerClassificationFunctional connectivityFunctional neurological disorderResting state functional magnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Neurology

Background:

  • Motor functional neurological disorder (mFND) presents diagnostic challenges due to patient reluctance and physician uncertainty.
  • A reliable biomarker is needed to reduce misdiagnosis, unnecessary costs, and facilitate early intervention.

Purpose of the Study:

  • To evaluate resting-state (RS) functional magnetic resonance imaging (fMRI) for discriminating between mFND patients and healthy controls.
  • To explore the potential of RS functional connectivity (FC) as a diagnostic biomarker for mFND.

Main Methods:

  • Classified 23 mFND patients and 25 healthy controls using whole-brain RS FC data.
  • Employed a support vector machine classifier with the Automated Anatomic Labeling (AAL) atlas and two additional atlases for validation.

Main Results:

  • Achieved classification accuracy, specificity, and sensitivity exceeding 68% (p=0.004) between mFND patients and controls.
  • Identified hyperconnectivity in the right caudate, amygdala, prefrontal, and sensorimotor regions in mFND patients compared to controls.

Conclusions:

  • RS FC demonstrates significant potential as a biomarker for mFND.
  • The findings suggest RS FC can aid in the individual-level clinical diagnosis of mFND.