Related Experiment Video
Updated: Feb 20, 2026
07:39
Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
Published on: August 4, 2023
3.0K
Conjunctival Blue Naevus in an Anophthalmic Socket.
Hibba Quhill1, Paul A Rundle2, Hardeep Singh Mudhar3
1Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.
Ocular Oncology and Pathology
|October 27, 2017
Summary
A rare conjunctival nevus, a type of benign pigmented lesion, was found in a 16-year-old male's anophthalmic socket. This case highlights the importance of monitoring such lesions for potential melanoma transformation.
Area of Science:
- Ophthalmology
- Dermatology
- Pathology
Background:
- Anophthalmic sockets can develop various lesions after eye removal.
- Conjunctival pigmentation in an anophthalmic socket is uncommon.
- Previous ocular trauma and enucleation preceded the lesion's appearance.
Purpose of the Study:
- To document an unusual case of conjunctival pigmentation in an anophthalmic socket.
- To characterize the histopathological and immunohistochemical features of the lesion.
- To discuss the potential pathogenesis and management of this rare finding.
Main Methods:
- Clinical examination of a 16-year-old male with an anophthalmic socket.
- Biopsy of a pigmented conjunctival lesion.
- Histopathological analysis and immunohistochemistry (Melan A, HMB45, CD68, pan-cytokeratins).
Main Results:
- A flat, subepithelial, dark brown pigmented lesion with irregular borders was identified.
- Biopsy revealed a conjunctival, subepithelial melanocytic lesion consistent with a blue nevus.
- Immunohistochemistry confirmed melanocytic origin and ruled out other cell types.
Conclusions:
- This is the first reported case of a conjunctival nevus in an anophthalmic socket.
- A pathogenesis involving post-enucleation changes is proposed.
- Regular surveillance is recommended due to the potential risk of melanoma transformation.
Related Concept Videos
01:17Accessory Structures of the Eye
3.9K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
3.9K
01:20Muscles of the Eye
4.7K
The muscles of the eye are sophisticated structures that control eye movement and focus, allowing for the precise and rapid adjustments necessary for vision. The human eye is controlled by ten muscles — six extraocular muscles, three intraocular muscles, and one primary eyelid retractor muscle.
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
Extraocular Muscles
The six extraocular muscles surround the eyeball and control its movements. They are responsible for a wide range of eye motions, including looking up, down, left, right, and...
4.7K
01:27Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
01:28Angle Closure Glaucoma: Treatment
1.4K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
01:19Veins of Head and Neck
6.0K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
6.0K
01:20Anatomy of the Eyeball
10.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
10.0K