Related Experiment Video
Updated: Feb 20, 2026
08:45
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
2.5K
Immunometabolism, pregnancy, and nutrition
Kristin Thiele1, Lianghui Diao1,2, Petra Clara Arck3
1Department of Obstetrics and Fetal Medicine, Laboratory for Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Seminars in Immunopathology
|October 27, 2017
Summary
Immunometabolism, the study of immune cell metabolism, is crucial for understanding reproduction. This review explores how metabolic reprogramming impacts maternal immune adaptation for successful pregnancy.
Area of Science:
- Immunometabolism
- Reproductive immunology
Background:
- Immunometabolism research has advanced significantly, revealing metabolic regulators of immune cells.
- However, immunometabolic reprogramming during reproduction remains poorly understood.
- Successful pregnancy requires maternal immune adaptation to fetal antigens.
Purpose of the Study:
- To review the role of immunometabolism in the molecular and cellular mechanisms of successful reproduction.
- To highlight the influence of maternal factors on immune cell metabolism during pregnancy.
Main Methods:
- Literature review of immunometabolism and reproductive immunology.
- Analysis of molecular and cellular mechanisms involved in maternal immune adaptation.
Main Results:
- Metabolic pathways significantly influence immune cell function in various contexts.
- Pregnancy involves complex maternal immune adaptations, including innate and adaptive immune cell modulation.
- Immunometabolism offers potential therapeutic strategies for reproductive health.
Conclusions:
- Immunometabolism plays a critical role in the immune adaptations necessary for successful reproduction.
- Maternal anthropometric and nutritional factors may influence immune cell metabolism, impacting pregnancy outcomes.
- Targeted metabolic reprogramming presents a potential therapeutic avenue for reproductive immune disorders.
Related Concept Videos
01:22Development of Immunocompetence
1.0K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.0K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
208
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
208
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
258
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
258
01:15Transcytosis of IgG
4.2K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.2K
01:22Diabetes Mellitus: Type 2 and Gestational
5.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
01:07Teratogenicity
4.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.3K