Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal studies on human schistosomiasis.

A E Butterworth1, A J Fulford, D W Dunne

  • 1Molteno Laboratories of Parasitology, Department of Pathology, University of Cambridge, U.K.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|October 31, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro.

Parasite immunology·2016
Same author

A pressing need for parasite immunologists to contribute to our understanding of human-neglected tropical diseases.

Parasite immunology·2014
Same author

A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils.

Parasite immunology·2013
Same author

Role of nociceptin/orphanin FQ and NOP receptors in the response to acute and repeated restraint stress in rats.

Journal of neuroendocrinology·2012
Same author

Risk factors for mortality in smear-negative tuberculosis suspects: a cohort study in Harare, Zimbabwe.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2012
Same author

Nociceptin/orphanin FQ and the regulation of neuronal excitability in the rat bed nucleus of the stria terminalis: interaction with glucocorticoids.

Stress (Amsterdam, Netherlands)·2010
Same journal

The microlandscapes of tree trunks: the effect of lichen and tree-level characteristics on arthropod communities.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Centimetre-scale landscapes to assess the motion behaviour and cognition of gastropods and bivalves.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Intertidal microcosms of wave-swept rocky shores: ecological and physiological insights from a uniquely stressful environment.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Temporal and spatial variation in temperature and oxygen at the microscale: key niche axes for aquatic life.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Natural microcosms in ecology: fulfilling the promise of model systems?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same journal

Microbe-induced galls and plant defence: metabolite crosstalk in a co-evolutionary battle.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
See all related articles

Schistosomiasis reinfection declines with age due to both reduced water contact and developing immunity. This acquired resistance, potentially immunological, is crucial for understanding disease epidemiology and developing vaccines.

Area of Science:

  • Immunology
  • Epidemiology
  • Infectious Diseases

Background:

  • Distinguishing acquired immunity from reduced exposure is challenging in human schistosomiasis epidemiology.
  • Observed declines in superinfection/reinfection in older individuals require clarification of underlying mechanisms.

Purpose of the Study:

  • To investigate the reasons for declining Schistosoma mansoni reinfection intensities in individuals after chemotherapy.
  • To differentiate the roles of acquired immunity versus reduced water contact in controlling reinfection.

Main Methods:

  • Studied reinfection intensities in Kenyan individuals post-chemotherapy.
  • Correlated reinfection levels with subsequent observations of water contact exposure.
  • Analyzed age- and infection-history-dependent resistance patterns.

Related Experiment Videos

Main Results:

  • Reinfection intensities were highest in young children and decreased sharply with age.
  • Age-related changes in exposure partially explained the decline; acquired resistance was also evident.
  • Evidence suggests acquired immunity develops with age and previous infection, possibly mediated by immune responses.

Conclusions:

  • Both reduced exposure and age-dependent acquired immunity contribute to lower Schistosoma mansoni reinfection in older individuals.
  • The development of acquired immunity may be linked to the interplay of protective and blocking immune responses.
  • Findings have implications for developing effective vaccination strategies against schistosomiasis.