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Childhood Brucellosis in Eastern India

Devarati Dutta1, Anindita Sen2, Debkishore Gupta3

  • 1Brucella Research Laboratory, Peerless Hospital & B.K. Roy Research Centre, 360 Panchasayar, Kolkata, West Bengal, 700094, India.

Indian Journal of Pediatrics
|October 27, 2017
PubMed

Insights

Childhood brucellosis is a significant concern in Eastern India, with higher infection rates observed in girls. Early diagnosis through various tests is crucial for managing this pyrexia of unknown origin (PUO) in children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Brucellosis is a zoonotic bacterial infection with significant global health implications.
  • Childhood brucellosis often presents with non-specific symptoms, making diagnosis challenging.
  • Pyrexia of unknown origin (PUO) is a common presentation of brucellosis in endemic areas.

Purpose of the Study:

  • To investigate the prevalence and characteristics of childhood brucellosis among PUO cases in Eastern India.
  • To evaluate the utility of different diagnostic methods for childhood brucellosis.

Main Methods:

  • A hospital-based study was conducted on pediatric patients (≤18 years) presenting with PUO.
  • Blood samples were analyzed using Standard Agglutination Test (STAT), Rose Bengal Plate Test (RBPT), ELISA-IgM, ELISA-IgG, and Brucella genus-specific PCR.
  • Clinical manifestations associated with brucellosis were also recorded.

Main Results:

  • Brucellosis was diagnosed in a notable percentage of children with PUO.
  • Infection rates were higher in female children (14.3%) compared to male children (10.9%).
  • Positive results were obtained for STAT (10.6%), RBPT (7.2%), ELISA-IgM (7.2%), ELISA-IgG (0.85%), and PCR (1.3%).
  • Commonly associated symptoms included joint pain, low backache, fatigue, and night sweats.

Conclusions:

  • Childhood brucellosis is a significant health issue in Eastern India, particularly among PUO cases.
  • The findings highlight the need for increased awareness and targeted diagnostic approaches for brucellosis in pediatric PUO patients.
  • Further epidemiological surveillance and monitoring are recommended to manage childhood brucellosis effectively.
Abstract

Keywords:
Childhood brucellosisELISAPCRPUORBPTSTAT

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