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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Childhood Brucellosis in Eastern India.

Devarati Dutta1, Anindita Sen2, Debkishore Gupta3

  • 1Brucella Research Laboratory, Peerless Hospital & B.K. Roy Research Centre, 360 Panchasayar, Kolkata, West Bengal, 700094, India.

Indian Journal of Pediatrics
|October 27, 2017
PubMed
Summary

Childhood brucellosis is a significant concern in Eastern India, with higher infection rates observed in girls. Early diagnosis through various tests is crucial for managing this pyrexia of unknown origin (PUO) in children.

Keywords:
Childhood brucellosisELISAPCRPUORBPTSTAT

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Brucellosis is a zoonotic bacterial infection with significant global health implications.
  • Childhood brucellosis often presents with non-specific symptoms, making diagnosis challenging.
  • Pyrexia of unknown origin (PUO) is a common presentation of brucellosis in endemic areas.

Purpose of the Study:

  • To investigate the prevalence and characteristics of childhood brucellosis among PUO cases in Eastern India.
  • To evaluate the utility of different diagnostic methods for childhood brucellosis.

Main Methods:

  • A hospital-based study was conducted on pediatric patients (≤18 years) presenting with PUO.
  • Blood samples were analyzed using Standard Agglutination Test (STAT), Rose Bengal Plate Test (RBPT), ELISA-IgM, ELISA-IgG, and Brucella genus-specific PCR.
  • Clinical manifestations associated with brucellosis were also recorded.

Main Results:

  • Brucellosis was diagnosed in a notable percentage of children with PUO.
  • Infection rates were higher in female children (14.3%) compared to male children (10.9%).
  • Positive results were obtained for STAT (10.6%), RBPT (7.2%), ELISA-IgM (7.2%), ELISA-IgG (0.85%), and PCR (1.3%).
  • Commonly associated symptoms included joint pain, low backache, fatigue, and night sweats.

Conclusions:

  • Childhood brucellosis is a significant health issue in Eastern India, particularly among PUO cases.
  • The findings highlight the need for increased awareness and targeted diagnostic approaches for brucellosis in pediatric PUO patients.
  • Further epidemiological surveillance and monitoring are recommended to manage childhood brucellosis effectively.