[Qilin Pills for obstructive azoospermia after ejaculatory duct reconstruction]

Area of Science:

• Reproductive Medicine
• Andrology
• Pharmacology

Background:

• Obstructive azoospermia is a leading cause of male infertility.
• Microsurgical ejaculatory duct reconstruction (MEDR) is a surgical option for treating obstructive azoospermia.
• Improving sperm quality post-surgery is crucial for successful conception.

Purpose of the Study:

• To evaluate the clinical efficacy of Qilin Pills in enhancing sperm quality.
• To assess the effect of Qilin Pills on severe oligozoospermia following MEDR.
• To compare sperm parameters between patients treated with Qilin Pills and placebo.

Main Methods:

• Retrospective analysis of 75 obstructive azoospermia patients undergoing MEDR.
• Patients were divided into a Qilin Pill group (n=42) and a placebo control group (n=33).
• Sperm quality was assessed after 3 months of postoperative medication.

Main Results:

• Significant improvement in sperm quality observed in all patients (P<0.05).
• Qilin Pill group showed dramatically increased sperm concentration compared to controls (2.83±0.59 vs 1.72±0.52 ×10⁶/ml, P<0.05).
• Increased percentages of grade a sperm, grade a+b sperm, and morphologically normal sperm in the Qilin group, though motility and morphology showed no significant inter-group differences.

Conclusions:

• Qilin Pills demonstrate considerable effectiveness in improving sperm quantity post-MEDR for obstructive azoospermia.
• The study supports Qilin Pills as a beneficial adjunct therapy for enhancing sperm production in these patients.
• Further research may explore optimal dosages and long-term effects.