Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.8K
T Cell Types and Functions01:24

T Cell Types and Functions

2.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guselkumab Safety in Patients With Latent Tuberculosis: Analysis of 11 Studies in Psoriatic Disease.

The Journal of dermatology·2026
Same author

Impact of Biologic Treatment Duration on Drug-Free Remission in Moderate-to-Severe Psoriasis: A Retrospective Cohort Study.

Dermatology and therapy·2026
Same author

A Narrative Review: Do Systemic Drugs Used in the Treatment of Psoriatic Disease Affect Alzheimer's Disease?

Dermatology and therapy·2026
Same author

Systemic Treatment Strategies for Patients with Psoriasis and Psoriatic Arthritis in the Setting of ANA Positivity or Lupus Spectrum Disease: A Comprehensive Systematic Review.

International journal of molecular sciences·2026
Same author

Ethnic Differences of Palmoplantar Pustulosis: A Systematic Review.

American journal of clinical dermatology·2025
Same author

How Cells Die in Psoriasis?

International journal of molecular sciences·2025
Same journal

Correction to: Mosaic disorders affecting pigmentation - part 1: how to make a clinical diagnosis.

The British journal of dermatology·2026
Same journal

Biett's Sign: A Diagnostic Clue to Secondary Syphilis.

The British journal of dermatology·2026
Same journal

Shallow Cuts, Deeper Issues: The Primacy of Deep Margins in Cutaneous Squamous Cell Carcinoma.

The British journal of dermatology·2026
Same journal

Management Patterns and Repigmentation Outcomes in Pediatric Segmental Versus Non-segmental Vitiligo: A Single-center Retrospective Study (2015-2024).

The British journal of dermatology·2026
Same journal

Quality-of-Life Measurement in Migrants and Other Vulnerable Groups: Experience with Skindex-16 in Malta and Lebanon.

The British journal of dermatology·2026
Same journal

Does loss of chromosome Y in blood contribute to the sex disparity of dermatitis and eczema at older ages?

The British journal of dermatology·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.2K

HLA-Cw6 and psoriasis.

L Chen1, T-F Tsai2

  • 1Lake Erie College of Osteopathic Medicine, Bradenton, PA, U.S.A.

The British Journal of Dermatology
|October 27, 2017
PubMed
Summary
This summary is machine-generated.

The human leukocyte antigen HLA-Cw6 allele is strongly linked to psoriasis, influencing disease onset, presentation, and treatment response. Understanding HLA-Cw6

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

952
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.3K

Related Experiment Videos

Last Updated: Feb 20, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.2K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

952
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.3K

Area of Science:

  • Immunogenetics
  • Dermatology
  • Genetic Epidemiology

Background:

  • Psoriasis is a complex, multifactorial skin disease with a significant genetic component.
  • The human leukocyte antigen (HLA) HLA-Cw6 allele is a major genetic risk factor for psoriasis.
  • The specific roles and clinical implications of HLA-Cw6 in psoriasis pathogenesis and progression require comprehensive review.

Purpose of the Study:

  • To systematically review and synthesize the existing knowledge on the association between HLA-Cw6 and psoriasis.
  • To explore the influence of HLA-Cw6 on psoriasis phenotype, disease severity, comorbidities, and treatment outcomes.
  • To highlight ethnic variations in HLA-Cw6 frequency and its clinical relevance.

Main Methods:

  • Literature review of studies investigating the association between HLA-Cw6 and psoriasis.
  • Analysis of data concerning disease course, phenotypic characteristics, and treatment responses in HLA-Cw6-positive individuals.
  • Examination of epidemiological data on HLA-Cw6 allele frequency across different ethnic groups.

Main Results:

  • HLA-Cw6 is strongly associated with early-onset (Type I) psoriasis, particularly guttate forms.
  • Patients with HLA-Cw6 often exhibit increased likelihood of trunk, limb, and Koebner phenomenon involvement.
  • HLA-Cw6 positivity correlates with better response to methotrexate and ustekinumab, though efficacy differences can be moderate.

Conclusions:

  • HLA-Cw6 is a significant genetic marker influencing psoriasis susceptibility, clinical presentation, and therapeutic response.
  • The allele's frequency and impact vary across ethnic populations, necessitating tailored research.
  • Further studies are crucial to fully elucidate the multifaceted role of HLA-Cw6 in diverse psoriasis patient groups.