Related Experiment Video
Updated: Feb 20, 2026

High-Pressure NMR Experiments for Detecting Protein Low-Lying Conformational States
Published on: June 29, 2021
Pressure effects on collective density fluctuations in water and protein solutions
Daniela Russo1,2, Alessio Laloni3, Alessandra Filabozzi4
1Istituto Officina dei Materiali, Consiglio Nazionale delle Ricerche, Institut Laue Langevin, 38042 Grenoble, France; russo@ill.fr heyden@kofo.mpg.de.
Abstract:
Neutron Brillouin scattering and molecular dynamics simulations have been used to investigate protein hydration water density fluctuations as a function of pressure. Our results show significant differences between the pressure and density dependence of collective dynamics in bulk water and in concentrated protein solutions. Pressure-induced changes in the tetrahedral order of the water HB network have direct consequences for the high-frequency sound velocity and damping coefficients, which we find to be a sensitive probe for changes in the HB network structure as well as the wetting of biomolecular surfaces.
Related Concept Videos
Pressure of Fluids
Pressure Variation in a Fluid at Rest
When measuring pressure at two different levels within the fluid, the difference in...
Fluid Pressure
According to Pascal's law, a fluid at rest will generate equal pressure in all directions. This pressure is measured as a force per unit area, and its magnitude depends on the fluid's specific...
Density
Protein Diffusion in the Membrane
Van der Waals Interactions

