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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Metabolomics toward personalized medicine.
Minnie Jacob1,2, Andreas L Lopata2, Majed Dasouki1
1Department of Genetics, King Faisal Specialist Hospital and Research Center (KFSH-RC), Riyadh, Saudi Arabia.
Mass Spectrometry Reviews
|October 27, 2017
Summary
Metabolomics profiling identifies disease biomarkers for personalized medicine. This review evaluates strategies for discovering diagnostic and prognostic biomarkers to advance precision healthcare.
Area of Science:
- Biochemistry
- Genomics
- Proteomics
- Metabolomics
Background:
- Metabolomics, the profiling of metabolites, is crucial for biomarker discovery and personalized medicine.
- Disease states exhibit distinct metabolic profiles reflecting cellular activities.
- Metabolomics constitutes over 95% of clinical laboratory workload worldwide.
Purpose of the Study:
- To review and evaluate metabolomics strategies for biomarker discovery.
- To focus on biomarkers with personalized diagnostic, prognostic, and therapeutic value.
- To assess biomarkers for monitoring disease progression and treatment response.
Main Methods:
- Analysis of diverse biological systems using various analytical platforms (NMR, MS, UPLC).
- Integration of metabolomics with genomics, transcriptomics, and proteomics.
- Evaluation of existing metabolomics studies and strategies.
Main Results:
- Metabolomics has identified numerous biomarkers for complex clinical phenotypes.
- Many clinically relevant metabolites are not yet routinely detectable.
- Combined multi-omics approaches enhance understanding of disease mechanisms.
Conclusions:
- Metabolomics is a key tool for biomarker discovery and personalized medicine.
- Integrating metabolomics with other omics fields advances precision healthcare.
- Further development is needed for detecting all clinically relevant metabolites.
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