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Isolation versus Enrichment: dCLIP Enables Stringent Profiling of RNA-Binding Sites

Eric L Van Nostrand1

  • 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.

Cell Systems
|October 27, 2017
PubMed

Abstract:

Denaturing crosslinking and immunoprecipitation (dCLIP) enables stringent purification of ribonucleoprotein complexes to identify direct RNA targets of individual protein complex members.

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