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Related Experiment Video

Updated: Feb 20, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
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Huntington's Disease: Premotor Phase.

Ana Rita Saldanha Ramos1, Carolina Garrett

  • 1Faculty of Medicine, University of Porto, Porto, Portugal.

Neuro-Degenerative Diseases
|October 27, 2017
PubMed
Summary

Huntington's disease (HD) diagnosis often misses early cognitive and psychiatric symptoms. Recognizing these premotor signs is crucial for timely intervention and improved patient outcomes.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, psychiatric, and cognitive symptoms.
  • Current diagnosis relies on motor symptoms and genetic testing, often overlooking earlier signs.

Purpose of the Study:

  • To review evidence on premotor symptoms of Huntington's disease.
  • To summarize recent studies on early cognitive and neuropsychiatric manifestations.

Main Methods:

  • Literature review of recent, robust studies on Huntington's disease.
  • Analysis of reported cognitive and neuropsychiatric symptoms in the premotor phase.

Main Results:

  • Premotor phase shows increased depression, anxiety, apathy, irritability, psychosis, disinhibition, hostility, and sleep disturbances.
Keywords:
DiagnosisHuntington’s diseasePremotor phase

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  • Cognitive impairments include deficits in attention, working memory, episodic memory, language, facial emotion recognition, empathy, and theory of mind.

    • Conclusions:

    • Early cognitive and neuropsychiatric symptoms in HD are significant but often disregarded.
    • Acknowledging these symptoms can lead to earlier diagnosis and intervention.
    • Earlier diagnosis enables neuroprotective therapies, potentially slowing progression and improving quality of life.