Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Integration of Synaptic Events01:28

Integration of Synaptic Events

4.3K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
4.3K
Depth Perception and Spatial Vision01:15

Depth Perception and Spatial Vision

2.2K
Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.
2.2K
Somatosensory, Motor, and Association Cortex01:23

Somatosensory, Motor, and Association Cortex

2.8K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
2.8K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.7K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.7K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

8.0K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
8.0K
Storage01:23

Storage

421
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
421

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HCN1 is a primary HCN Pacemaker Channel in Neurons.

Nature communications·2026
Same author

The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology.

Molecular psychiatry·2025
Same author

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes.

bioRxiv : the preprint server for biology·2025
Same author

Synaptic interactions between stellate cells and parvalbumin interneurons in layer 2 of the medial entorhinal cortex are organized at the scale of grid cell clusters.

eLife·2024
Same author

Learning-dependent gating of hippocampal inputs by frontal interneurons.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour.

eLife·2024
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
Same journal

Noninvasive decoding of typed sentences from human brain activity.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Feb 20, 2026

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

2.8K

Synaptic integrative mechanisms for spatial cognition.

Christoph Schmidt-Hieber1, Matthew F Nolan2

  • 1Institut Pasteur, Paris, France.

Nature Neuroscience
|October 27, 2017
PubMed
Summary
This summary is machine-generated.

Synaptic integration profoundly impacts brain electrical signaling, influencing how we encode, store, and retrieve information. This review explores its role in spatial coding and memory, highlighting key research questions.

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K
Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K

Related Experiment Videos

Last Updated: Feb 20, 2026

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice
08:59

An Open-Source Virtual Reality System for the Measurement of Spatial Learning in Head-Restrained Mice

Published on: March 3, 2023

2.8K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K
Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cognitive Neuroscience

Background:

  • Synaptic integration significantly influences neuronal electrical signaling.
  • These mechanisms are crucial for information processing but often unobserved by standard electrophysiological methods.
  • Understanding synaptic integration is key to deciphering brain function in spatial memory.

Purpose of the Study:

  • To review the roles of synaptic integrative mechanisms in spatial coding.
  • To examine their involvement in the plasticity of place and grid fields.
  • To discuss challenges in testing computational models of spatial memory.

Main Methods:

  • Literature review of synaptic integration in neuroscience.
  • Analysis of studies on place cells and grid cells.
  • Discussion of computational models for spatial representation.

Main Results:

  • Synaptic integration is vital for selecting, generating, and modifying place and grid fields.
  • Temporal codes for spatial representation are influenced by synaptic mechanisms.
  • Current models of spatial computation and memory require further empirical testing.

Conclusions:

  • Synaptic integrative mechanisms are fundamental to neural representations of space.
  • Further research is needed to validate computational models of spatial memory.
  • Bridging the gap between synaptic function and cognitive processes remains a key challenge.