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Lithium Intoxication: A Possible Interaction with Moxifloxacin
Selvi Kayipmaz1, Ali Ercan Altınöz1, Nadide Elmas Gülcü Ok1
1Department of Psychiatry, Baskent University Faculty of Medicine, Ankara, Turkey.
Summary
Elderly patients on lithium carbonate for mood disorders are at risk of intoxication, especially with infections like bronchiolitis. Prompt cessation of lithium and supportive care are crucial for recovery.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Neurology
Background:
- Lithium carbonate is a primary treatment for mood disorders.
- Elderly individuals face increased risks of lithium intoxication due to physiological changes and polypharmacy.
Observation:
- A 74-year-old female, stable on lithium carbonate for 5 years, developed lithium intoxication following bronchiolitis.
- The patient presented with altered mental status, a key indicator of lithium toxicity.
Findings:
- Neurological symptoms gradually resolved after immediate discontinuation of lithium carbonate and moxifloxacin, coupled with fluid resuscitation.
- This case highlights the potential for infections to precipitate lithium toxicity in the elderly.
Implications:
- Careful consideration of potential drug interactions and patient comorbidities is essential when prescribing lithium to elderly patients.
- Monitoring lithium levels and potential toxicities is critical, particularly in older adults experiencing acute illness.
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