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Updated: Feb 20, 2026

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
Published on: February 12, 2015
Standardisation and half-life of 89Zr
E García-Toraño1, V Peyrés1, M Roteta1
1Laboratorio de Metrología de Radiaciones Ionizantes, CIEMAT Avda. Complutense 40, Madrid 28040, Spain.
Abstract:
The nuclide 89Zr is being tested for the labelling of compounds with long blood circulation times. It decays by beta plus emission (22.8%) and by electron capture (77.2%) to 89Y. Its half-life has been determined by following the decay rate with two measurement systems; an Ionisation Chamber and an HPGe detector. The combination of six results gives a value of T1/2 = 78.333 (38) h, slightly lower than the DDEP recommended value of 78.42 (13) h. This radionuclide has also been standardised by liquid scintillation counting, 4πγ counting and coincidence techniques.
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