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Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Alexandre Leme Godoy-Santos1, Homero Bruschini2, Jose Cury2

  • 1Department of Orthopaedics and Traumatology, University of São Paulo, São Paulo, São Paulo, Brazil.

Urology
|October 28, 2017
PubMed
Abstract

Insights

Fluoroquinolone antibiotics, commonly used for urinary infections, are linked to Achilles tendon issues. Male gender, older age, and corticosteroid use are key risk factors for this complication.

Area of Science:

  • Pharmacology
  • Orthopedics
  • Infectious Diseases

Background:

  • Fluoroquinolones (FQ) are frequently prescribed for uncomplicated urinary tract infections.
  • FQ use has been associated with Achilles tendon disorders, particularly within the initial month of treatment.

Purpose of the Study:

  • To review existing research on fluoroquinolone-associated Achilles tendon disorders.
  • To identify specific risk factors contributing to the incidence of this complication.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, MEDLINE, and Scopus.
  • Data were collected from articles published between January 1988 and June 2017.

Main Results:

  • The review analyzed data from 79 articles.
  • Ciprofloxacin was identified as the most frequently studied fluoroquinolone in relation to tendon disorders.

Conclusions:

  • Male sex, advanced age, normal BMI, chronic renal failure, and concomitant corticosteroid use are associated with an increased risk.
  • These factors should be considered when prescribing fluoroquinolones to mitigate Achilles tendon disorder risk.

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