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The local modulation of vascular permeability by endothelial cell derived products
C L Chander1, A R Moore, F M Desa
1Department of Experimental Pathology, St Bartholomew's Hospital Medical College, London, UK.
The Journal of Pharmacy and Pharmacology
|October 1, 1988
Abstract:
Endothelin has been shown to suppress increased vascular permeability in the rat at doses of 0.01 pmol. The agonists used were nitric oxide and nitroprusside, which have the same activity as endothelial-derived relaxing factor. Histamine, 5-hydroxytryptamine, platelet activating factor and carrageenan were the other agonists used. It is proposed that endothelin and EDRF act as local hormones produced by endothelial cells to control local vascular permeability.