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Application of difference spectroscopy to the determination of some pharmaceutically important nitro compounds
S M Hassan1, M Sharaf el-Din, F Belal
1Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
The Journal of Pharmacy and Pharmacology
|November 1, 1988
Abstract:
A simple and selective spectrophotometric method for the determination of some pharmaceutically important nitro compounds has been developed. The suggested method depends upon the spectral changes induced by reduction using either Zn/HCl or Zn/NH4Cl. The different experimental parameters were studied and incorporated into the procedure. The mean percentage recovery ranged from 99 to 101. The proposed method was applied to the determination of the studied compounds in dosage forms, and the results obtained were compared favourably with those given with the compendial ones.