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Updated: Feb 20, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College
Qiong Zhou1,2, Xiao-Juan Zhu1,2, Jiang-Hua Li1,2
1Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University, Nanchang, China.
Abstract:
Some reports have shown that nicotinamide N-methyltransferase (NNMT) is associated with the body mass index (BMI) and energy metabolism. Here we explored the association between NNMT gene polymorphisms and obesity. The subjects were recruited from male Chinese Han college student. 289 of them (19 ≤ body fat percentage (BF%)) were selected as the high body fat group (HBFG), 494 of them (3 ≤ BF% < 13.5) were selected as the low body fat group (LBFG), and then a case-control study (fat versus thin) was carried out to explore the association between the NNMT gene polymorphism and the body composition using tagSNPs method. A tagSNP (rs10891644) in NNMT gene was found significantly associated with the body composition (P < 0.0026). At this locus, the BF% for the genotype GT, TT, and GG were 14.56 ± 8.35, 13.47 ± 8.11, and 12.42 ± 7.50, respectively, and the differences between the GT and the GG + TT were highly significant (P < 0.01); the ORadjusted value of the GT versus (GG + TT) was 1.716 (Padjusted = 0.002, 95% CI = 1.240-2.235). Therefore, the variation of the tagSNP, rs10891644, is significantly associated with obesity and the GT carriers are the susceptible population.
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