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Dendritic Cells in Sepsis: Pathological Alterations and Therapeutic Implications
Dong-Dong Wu1,2, Tao Li1, Xin-Ying Ji1,3
1School of Medical Sciences, College of Medicine, Henan University, Kaifeng, Henan 475004, China.
Journal of Immunology Research
|October 28, 2017
Summary
Sepsis significantly impacts dendritic cells (DCs), crucial immune regulators. This review explores DC alterations in sepsis and discusses therapeutic strategies targeting DCs to improve outcomes.
Area of Science:
- Immunology
- Critical Care Medicine
Background:
- Sepsis is a major cause of mortality in critically ill patients.
- Dendritic cells (DCs) are key antigen-presenting cells regulating innate and adaptive immunity.
- Sepsis alters DC number, differentiation, and function, impacting immune responses.
Purpose of the Study:
- To review DC subset classifications and mechanisms of DC alteration in sepsis.
- To discuss therapeutic strategies targeting DCs for sepsis management.
Main Methods:
- Literature review of studies on dendritic cells and sepsis.
- Analysis of mechanisms affecting DCs during sepsis, including apoptosis, oxidative stress, Wnt signaling, epigenetics, and TLR signaling.
- Exploration of therapeutic approaches targeting DCs in sepsis.
Main Results:
- Sepsis induces significant changes in dendritic cell populations and function.
- Multiple molecular pathways, including apoptosis, ROS, Wnt signaling, epigenetics, and TLRs, are implicated in DC dysfunction during sepsis.
- Targeting DCs presents potential therapeutic avenues for sepsis.
Conclusions:
- Understanding DC alterations in sepsis is crucial for developing effective treatments.
- Therapeutic strategies aimed at modulating DC function hold promise for improving sepsis outcomes.
- Further research into DC subsets and their roles in sepsis is warranted.
