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Transition metal-catalyzed C-H bond functionalization in multicomponent reactions: a tool toward molecular diversity
Jie-Ping Wan1, Lu Gan, Yunyun Liu
1College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China. chemliuyunyun@jxnu.edu.cn wanjieping@jxnu.edu.cn.
Abstract:
Transition metal-catalyzed C-H bond functionalization has numerous applications in organic synthesis as a powerful type of bond transformation. In particular, the combination of C-H functionalization with other types of chemical transformations in the manner of multicomponent reactions is an even more beneficial tool in the synthesis of small organic molecules because such reactions provide a platform for the rapid generation of high molecular diversity and complexity by making use of the advantages of both latent C-H bond transformation and the multicomponent reaction. Herein, we provide a review highlighting the research advances in the multicomponent reactions built upon transition metal-catalyzed C-H bond functionalization. The content spans from the reactions featuring the functionalization of C(sp3)-H, C(sp2)-H and C(sp)-H bonds over the last decade.
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