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Updated: Feb 20, 2026

Live-Cell Imaging of Transcriptional Activity at DNA Double-Strand Breaks
Published on: September 20, 2021
Regulation of DNA break repair by transcription and RNA
Jian Ouyang1, Li Lan2,3, Lee Zou4,5
1Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02129, USA.
Abstract:
Repair of DNA double-strand breaks (DSBs) via the homologous recombination (HR) pathway is a highly regulated process. A number of proteins that participate in HR are intricately modulated by the cell cycle and chromatin environments of DSBs. Recent studies have revealed a clear impact of transcription on HR in transcribed regions of the genome. Several models have been put forth to explain how the process of transcription and/or its RNA products may influence HR. Here we discuss the results and models from these studies, presenting an emerging view of transcription-coupled DSB repair.
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