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Endoscopic sutured gastroplasty: procedure evolution from first-in-man cases through current technique.
Nitin Kumar1, Barham K Abu Dayyeh2, Gontrand Lopez-Nava Breviere3
1Bariatric Endoscopy Institute, Addison, IL, USA.
Surgical Endoscopy
|October 28, 2017
Summary
Endoscopic sutured gastroplasty (ESG) using full-thickness sutures is a safe and effective obesity treatment. This trial demonstrated meaningful weight loss and procedural feasibility in patients.
Area of Science:
- Bariatric surgery
- Gastroenterology
- Minimally invasive procedures
Background:
- Endoscopic sutured gastroplasty (ESG) techniques have advanced, particularly with full-thickness endoscopic suturing.
- This study details the development and refinement of an efficient ESG technique.
Purpose of the Study:
- To evaluate the safety, reproducibility, and short-term efficacy of full-thickness endoscopic suturing for primary obesity therapy.
- To establish a standardized ESG technique through a multi-phase, multi-center trial.
Main Methods:
- A prospective, first-in-man trial conducted in three phases across five countries.
- Phase I: Procedure development and safety assessment. Phase II: Technique standardization. Phase III: Feasibility and weight loss evaluation in 77 patients.
Main Results:
- The standardized ESG technique demonstrated high conformity and feasibility.
- Patients achieved a mean weight loss of 17.4% at 12 months.
- Common side effects included nausea, vomiting, and epigastric pain; no significant adverse events were reported.
Conclusions:
- Methodical development led to a safe and effective ESG procedure.
- The trial confirmed ESG's short-term efficacy and meaningful weight loss potential for obesity treatment.
