Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

3.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
3.5K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

32
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
32
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

32
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
32

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of vedolizumab in pediatric intestinal transplant rejection.

Intestinal Failure (New York, N.Y.)·2026
Same author

Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation.

Cancer genomics & proteomics·2026
Same author

Data-driven risk stratification and zonal classification of postoperative fluid collections after pancreaticoduodenectomy.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2026
Same author

Second Report of the American Intestinal Transplant Working Group: New Insights Into Risk Factors, Treatment Regimens, and Outcomes of Malignancy After Intestinal Transplantation.

Transplantation·2026
Same author

Pediatric liver transplantation for metabolic diseases: a single-center experience.

World journal of pediatrics : WJP·2026
Same author

N-acetylcysteine modulates neutrophil-driven immune and metabolic pathways in steatotic liver ischemia-reperfusion injury.

Frontiers in immunology·2026

Related Experiment Video

Updated: Feb 20, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K

Nonhemolytic passenger lymphocyte syndrome.

S Gerald Sandler1, Suhua Han1, Albert Langeberg1

  • 1Department of Pathology and Laboratory Medicine, and the Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.

Transfusion
|October 28, 2017
PubMed
Summary

Passenger lymphocyte syndrome (PLS) can occur in transplant recipients. Early antibody screening in donors or recipients can detect PLS, including non-hemolytic cases, improving diagnosis and patient care.

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K
Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

14.3K

Related Experiment Videos

Last Updated: Feb 20, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.5K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

10.0K
Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

14.3K

Area of Science:

  • Transfusion Medicine
  • Immunology
  • Transplantation Science

Background:

  • Passenger lymphocyte syndrome (PLS) is a rare complication following transplantation.
  • It arises from donor lymphocytes transfused to the recipient, potentially causing alloimmunization.
  • This case highlights PLS in a liver transplant recipient with donor anti-C and anti-D antibodies.

Observation:

  • A literature review of 31 studies (63 cases) of PLS was conducted over 10 years.
  • Both hematopoietic stem cell and organ transplants were analyzed for PLS incidence and outcomes.
  • Hemolysis was a common outcome, observed in 100% of HSCT and 95% of organ transplant cases.

Findings:

  • PLS diagnosis is often reactive, focusing on hemolysis rather than proactive antibody detection.
  • Proactive screening detected PLS cases before hemolysis in both hematopoietic stem cell and organ transplants.
  • Non-hemolytic PLS cases may be missed with current diagnostic approaches.

Implications:

  • Current diagnostic practices for PLS may underestimate its full scope by focusing solely on hemolysis.
  • Implementing donor plasma antibody screening or routine recipient post-transplant antibody screening can improve PLS detection.
  • Recognizing hemolytic and non-hemolytic PLS subcategories is crucial for accurate diagnosis and management.