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Microfabricated Platforms for Mechanically Dynamic Cell Culture
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Engineered Paper-Based Cell Culture Platforms.

Darlin Lantigua1, Yan Ni Kelly2, Baris Unal3

  • 1Department of Biological Sciences, University of Massachusetts Lowell, One University Avenue, Lowell, MA, 01854, USA.

Advanced Healthcare Materials
|October 28, 2017
PubMed
Summary

Engineered paper platforms offer versatile, low-cost solutions for cell culture and analysis in biomedical research. These flexible biomaterials enable advanced tissue engineering and diagnostics, advancing personalized medicine.

Keywords:
biomaterialshydrogelspaper-based platformspersonalized medicinetissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Paper's tunable and flexible nature makes it suitable for biomedical research.
  • Paper-based platforms are compatible with various cell types and analytical assays.
  • The porous structure of paper eliminates mass transport limitations for cells.

Purpose of the Study:

  • To provide an overview of engineered paper-based biomaterials and platforms.
  • To highlight the applications of paper in cell culture, diagnostics, and separations.
  • To discuss the potential of paper in tissue engineering and personalized medicine.

Main Methods:

  • Review of recent advancements in engineered paper-based biomaterials.
  • Discussion of fabrication techniques for paper-based platforms (e.g., patterning, 3D assembly).
  • Analysis of paper's compatibility with different cell types and analytical assays.

Main Results:

  • Paper platforms can be engineered at various scales and in 3D configurations.
  • Multicellular and compartmentalized tissue mimetics can be fabricated using paper.
  • Cells can be recovered from paper scaffolds for further analysis.

Conclusions:

  • Engineered paper offers a versatile, low-cost biomaterial for cell culture and analysis.
  • Paper-based platforms facilitate the development of physiologically relevant tissue models for personalized medicine.
  • Layer-by-layer assembly strategies enable organ-on-paper applications and fundamental biological studies.