Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Relationships between plasma, CSF and brain tryptophan.

Journal of Neural Transmission. Supplementum

|January 1, 1979

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SUBSTANCES RELATED TO 5-HYDROXYTRYPTAMINE IN PLASMA AND IN LUMBAR AND VENTRICULAR FLUIDS OF PSYCHIATRIC PATIENTS.

Acta psychiatrica Scandinavica·2017

Same author

The absorption and metabolism of a standard oral dose of levodopa in patients with Parkinsonism.

British journal of clinical pharmacology·2012

Same author

Effects of food deprivation and mCPP treatment on the microstructure of ingestive behaviour of male and female rats.

Journal of psychopharmacology (Oxford, England)·2012

Same author

The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats.

Journal of psychopharmacology (Oxford, England)·2011

Same author

Serotonin neurochemistry revisited: A new look at some old axioms.

Neurochemistry international·2010

Same author

The serotonergic appetite suppressant fenfluramine. Reappraisal and rejection.

Advances in experimental medicine and biology·2000

Same journal

Intake of tomato-enriched diet protects from 6-hydroxydopamine-induced degeneration of rat nigral dopaminergic neurons.

Journal of neural transmission. Supplementum·2010

Same journal

A diet for dopaminergic neurons?

Journal of neural transmission. Supplementum·2010

Same journal

Immunization as treatment for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Gene therapy for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Stem cells and cell replacement therapy for Parkinson's disease.

Journal of neural transmission. Supplementum·2010

Same journal

Neurogenesis in substantia nigra of parkinsonian brains?

Journal of neural transmission. Supplementum·2010

See all related articles

Plasma free tryptophan, not total, better predicts brain tryptophan levels across various conditions. This relationship is crucial for understanding brain chemistry and its impact on neurological and psychiatric states.

Area of Science:

Neurochemistry
Biochemistry
Physiology

Background:

Plasma tryptophan exists in bound and free forms, influencing brain uptake.
Factors like immobilization, fasting, and liver failure affect plasma tryptophan levels and binding.

Purpose of the Study:

To investigate the correlation between plasma free tryptophan and brain tryptophan concentrations.
To determine the influence of plasma tryptophan binding on brain tryptophan uptake.
To assess the utility of plasma free tryptophan as an index for central nervous system serotonin turnover in humans.

Main Methods:

Utilized a modified Oldendorf method to assess brain tryptophan uptake.
Conducted experiments in rats following portocaval anastomosis and sham operations.

Related Experiment Videos

Analyzed plasma and cerebrospinal fluid (CSF) from psychiatric patients.

Main Results:

Plasma free tryptophan correlated more strongly with brain tryptophan than total plasma tryptophan.
Changes in plasma tryptophan binding significantly impacted brain tryptophan uptake.
Plasma free tryptophan concentration served as a reliable index for CSF tryptophan and 5-hydroxyindoleacetic acid levels in psychiatric patients.

Conclusions:

Plasma free tryptophan is a more accurate indicator of brain tryptophan levels than total plasma tryptophan.
Plasma tryptophan binding and free fatty acid concentrations play a key role in regulating brain tryptophan.
Plasma free tryptophan concentration can be used to estimate central nervous system serotonin turnover in humans.