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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Long-Term Magnetization Transfer Ratio Evolution in Multiple Sclerosis White Matter Lesions.

Yufan Zheng1,2, Jar-Chi Lee3, Richard Rudick4

  • 1Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|October 28, 2017
PubMed
Summary

Long-term Magnetization Transfer Ratio (MTR) changes in multiple sclerosis (MS) lesions reveal distinct lesion subtypes. These MTR changes correlate with disease progression and brain atrophy, offering insights into MS pathology.

Keywords:
Multiple sclerosislong-term lesion evolutionmagnetization transfer ratio

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Area of Science:

  • Neuroimaging
  • Magnetic Resonance Imaging (MRI)
  • Pathology

Background:

  • Magnetization transfer ratio (MTR) assesses tissue integrity and correlates with demyelination/axonal loss in multiple sclerosis (MS).
  • Short-term MTR changes in acute MS lesions reflect demyelination, remyelination, edema, and axonal/glial changes.
  • Long-term MTR changes in MS lesions remain understudied.

Purpose of the Study:

  • To develop and apply a quantitative image analysis method for measuring long-term MTR changes in MS lesions.
  • To investigate correlations between long-term MTR evolution, disability progression, and brain atrophy in MS patients.

Main Methods:

  • A quantitative image analysis method was developed to measure long-term MTR changes.
  • 59 MS patients and 14 healthy controls were followed for 4 years.
  • Lesion voxels were classified into six categories based on MTR and temporal change; proportions were calculated per patient.

Main Results:

  • The proportion of high, stable MTR lesion voxels correlated with less atrophy progression.
  • A higher proportion of low, increasing MTR lesion voxels correlated with increased atrophy.
  • MS disease subgroups showed significant differences in high, stable MTR lesion voxel proportions; progressive MS had more low, increasing MTR lesions.

Conclusions:

  • Long-term MTR changes in MS white matter lesions can distinguish subtypes associated with disease progression.
  • This approach enhances understanding of the temporal evolution of MS pathology.
  • MTR analysis offers a potential tool for characterizing MS lesion subtypes and progression.