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HEDD: Human Enhancer Disease Database.

Zhen Wang1, Quanwei Zhang1, Wen Zhang1

  • 1Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.

Nucleic Acids Research
|October 28, 2017
PubMed
Summary
This summary is machine-generated.

The Human Enhancer Disease Database (HEDD) links genomic enhancers to human diseases. This resource aids research into complex diseases by mapping millions of enhancers and their gene connections.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Human Genetics

Background:

  • Genomic enhancers are crucial cis-regulatory elements controlling gene transcription.
  • These elements are implicated in the pathogenesis of numerous complex human diseases.
  • Existing databases lack comprehensive annotation linking enhancers to disease associations.

Purpose of the Study:

  • To develop a comprehensive database annotating human enhancers and their connections to diseases.
  • To facilitate research on the roles of enhancers in human complex diseases.
  • To provide a centralized resource for genomic and disease association data of enhancers.

Main Methods:

  • Integrated data from ENCODE, FANTOM5, and RoadMap consortia for enhancer identification.
  • Developed disease association scores based on enhancer-gene and gene-disease networks.
  • Implemented web-based analytical tools for network visualization and enhancer scoring.

Main Results:

  • Compiled comprehensive genomic information for approximately 2.8 million human enhancers.
  • Established disease association scores for enhancers based on integrated biological networks.
  • Created a publicly accessible database (HEDD) with visualization and scoring tools.

Conclusions:

  • The Human Enhancer Disease Database (HEDD) provides a valuable resource for studying enhancer functions in human diseases.
  • HEDD facilitates the exploration of enhancer-gene-disease relationships.
  • The database supports advancements in understanding the genetic basis of complex human diseases.