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Packed Red Blood Cell Transfusion in Older Adults: A Systematic Review

Allison R Jones, Gwen McGhan, Jill Deaver

    Journal of Gerontological Nursing
    |October 28, 2017
    PubMed

    Insights

    Evidence on packed red blood cell (PRBC) transfusions in older adults (≥65) is limited. Further research is needed to evaluate interventions and outcomes for this population.

    Area of Science:

    • Gerontology
    • Transfusion Medicine
    • Evidence-Based Practice

    Background:

    • Packed red blood cell (PRBC) transfusion research predominantly excludes older adults (≥65).
    • Older adults present unique challenges due to comorbidities and complex care needs.
    • Existing evidence on PRBC transfusion in this demographic is insufficient.

    Purpose of the Study:

    • To systematically review and critically evaluate the current evidence on PRBC transfusions in patients aged 65 and older.
    • To identify gaps in knowledge regarding interventions and outcomes associated with PRBC transfusion in older adults.

    Main Methods:

    • Conducted a systematic literature search of PubMed, CINAHL, and Embase for randomized controlled trials.
    • Applied Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for study selection.
    • Assessed study bias using Standards for QUality Improvement Reporting Excellence (SQUIRE) guidelines.

    Main Results:

    • Identified 10 relevant studies focusing on cardiac, orthopedic, and gastrointestinal surgery patients.
    • Studies exhibited a low average bias score (13.0), with primary bias sources in data accuracy and reporting.
    • Interventions aimed at preventing PRBC transfusion in older adults were diverse.

    Conclusions:

    • The current body of evidence on PRBC transfusion in older adults is limited and requires expansion.
    • Further investigation is crucial to understand the efficacy of various transfusion interventions and their associated outcomes in this population.
    • High-quality research is needed to inform clinical practice for older adults receiving PRBC transfusions.

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