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Updated: Feb 20, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Prenatal substance exposure diagnosed at birth and infant involvement with child protective services
John J Prindle1, Ivy Hammond1, Emily Putnam-Hornstein1
1Children's Data Network, Suzanne Dworak-Peck School of Social Work, University of Southern California, United States.
Insights
Infants exposed to substances before birth face higher risks of child protective services (CPS) involvement. This study highlights significant variations in CPS reporting and foster care placement based on the type of substance exposure.
Area of Science:
- Pediatrics
- Public Health
- Social Work
Background:
- Infants experience the highest rates of maltreatment reports and foster care entries.
- Prenatal substance exposure is a suspected factor in early child protective services (CPS) involvement.
- Limited data exist on the relationship between prenatal substance exposure and CPS involvement, especially by substance type.
Purpose of the Study:
- To estimate the population prevalence of medically diagnosed prenatal substance exposure and neonatal withdrawal disorders.
- To examine the association between prenatal substance exposure and CPS involvement in the first year of life, considering substance type.
- To adjust for sociodemographic and health factors in analyzing CPS involvement rates.
Main Methods:
- Utilized linked birth, hospital discharge, and CPS records from California.
- Analyzed data for 551,232 infants born in 2006.
- Estimated population prevalence and explored CPS involvement rates, adjusting for covariates.
Main Results:
- 1.45% of infants were diagnosed with prenatal substance exposure at birth.
- 61.2% of exposed infants were reported to CPS before age one; 29.9% entered foster care.
- Prenatal substance exposure strongly predicted CPS involvement, with significant variations by substance type.
Conclusions:
- Medically diagnosed prenatal substance exposure is a significant pathway to CPS involvement in infancy.
- The type of substance exposed prenatally influences the likelihood and level of CPS intervention.
- Further research is necessary to understand the long-term outcomes for these infants and the role of CPS.
Abstract:
Infants have the highest rates of maltreatment reporting and entries to foster care. Prenatal substance exposure is thought to contribute to early involvement with child protective services (CPS), yet there have been limited data with which to examine this relationship or variations by substance type. Using linked birth, hospital discharge, and CPS records from California, we estimated the population prevalence of medically diagnosed substance exposure and neonatal withdrawal disorders at birth. We then explored the corresponding rates of CPS involvement during the first year of life by substance type after adjusting for sociodemographic and health factors. Among 551,232 infants born alive in 2006, 1.45% (n=7994) were diagnosed with prenatal substance exposure at birth; 61.2% of those diagnosed were reported to CPS before age 1 and nearly one third (29.9%) were placed in foster care. Medically diagnosed prenatal substance exposure was strongly associated with an infant's likelihood of being reported to CPS, yet significant variation in the likelihood and level of CPS involvement was observed by substance type. Although these data undoubtedly understate the prevalence of prenatal illicit drug and alcohol use, this study provides a population-based characterization of a common pathway to CPS involvement during infancy. Future research is needed to explicate the longer-term trajectories of infants diagnosed with prenatal substance exposure, including the role of CPS.
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