Related Experiment Video

Updated: Feb 20, 2026

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K

[Personalized therapy of lung cancer - current standard and future challenges]

Richard Riedel, Jürgen Wolf

    Deutsche Medizinische Wochenschrift (1946)
    |October 28, 2017
    PubMed

    Insights

    Personalized therapy has transformed non-small cell lung cancer (NSCLC) care. Molecular diagnostics and targeted drugs for specific mutations are now standard, though challenges like resistance remain.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacogenomics

    Background:

    • Personalized therapy has significantly advanced non-small cell lung cancer (NSCLC) treatment.
    • Molecular subtyping of NSCLC based on driver mutations is increasingly prevalent.

    Purpose of the Study:

    • To review the current landscape of personalized therapy in NSCLC.
    • To highlight approved targeted therapies and future challenges in NSCLC treatment.

    Main Methods:

    • Literature review of personalized medicine in NSCLC.
    • Analysis of approved targeted therapies for common driver mutations.
    • Discussion of emerging challenges and future directions.

    Main Results:

    • Approved first-line drugs are available for four key driver mutations: EGFR, ALK, ROS1, and BRAF-V600.
    • Numerous targeted therapies are in clinical development or used off-label.
    • Molecular diagnostics are crucial for classifying NSCLC patients.

    Conclusions:

    • Personalized therapy, driven by molecular diagnostics, is the standard of care for NSCLC.
    • Addressing therapeutic resistance and expanding targeted options for more mutations are critical future goals.

    More Related Videos

    Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer07:59

    Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

    Published on: September 8, 2023

    1.8K
    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer04:04

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

    Published on: February 12, 2017

    11.1K

    Related Concept Videos

    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    9.0K
    Combination Therapies and Personalized Medicine02:50

    Combination Therapies and Personalized Medicine

    Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
    The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
    6.2K
    Cancer Therapies02:49

    Cancer Therapies

    Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
    However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
    10.2K
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    2.0K
    Treatment Resistant Cancers02:56

    Treatment Resistant Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    3.8K
    Cancer Vaccines01:30

    Cancer Vaccines

    Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
    Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
    1.1K