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GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs

Shahar Barbash1, Emily Lorenzen1, Torbjörn Persson1,2

  • 1Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, 10065.

Proceedings of the National Academy of Sciences of the United States of America
|October 29, 2017
PubMed
Summary

Receptor activity-modifying proteins (RAMPs) and G-protein-coupled receptors (GPCRs) show global coevolution, suggesting widespread interactions in cellular signaling. This indicates functional redundancy and coordinated roles between RAMPs and GPCRs.

Keywords:
G-protein–coupled receptorcoevolutionphylogenetic analysisreceptor activity-modifying proteinsignal transduction

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