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Published on: July 14, 2023
Secondary Hyperparathyroidism in Heart Failure
Mohamed S Morsy1, Dwight A Dishmon1, Nadish Garg1
1Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, Tennessee.
Abstract:
Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca2+ and Mg2+ wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca2+ overloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Herein, we briefly review the presence and adverse outcomes of SHPT in persons with heart failure.
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