Related Experiment Videos
Returning from the acidotic abyss: Mortality in trauma patients with a pH < 7.0
Samuel W Ross1, Bradley W Thomas1, A Britton Christmas1
1Division of Acute Care Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.
Introduction:
We hypothesized that a pH of <7.0 on presentation would correlate with almost universal mortality in trauma patients.
Methods:
A retrospective cohort study was performed on a Level I trauma center registry from 2013 to 2014. Hospital mortality was the primary outcome, which was compared by pH cohort (<7.0 or ≥7.0) using standard univariate statistics and multivariate logistic regression.
Results:
There were 593 patients included in the analysis: 66 in <7.0, 527 in ≥7.0. Mortality was 3× higher in the <7.0 pH cohort (62.1 vs. 20.3%; p < 0.0001), however there was no threshold for a pH below which there was 100% mortality. After controlling for these confounding variables, initial pH was found to be an independent predictor of inpatient mortality: pH < 7.0 (OR 6.33, 3.29-12.19; p < 0.0001).
Conclusion:
This data indicates that while patients with severe acidosis are at increased risk for mortality, a pH < 7.0 is still recoverable in select cases.