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PDGF-C and PDGF-D in ocular diseases
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 South Xianlie Road, Guangzhou 510060, Guangdong, PR China.
Abstract:
PDGFs and their receptors are critical regulators of numerous tissues and organs, including the eye. Extensive studies have shown that PDGFs and their receptors play critical roles in many ocular neovascular diseases, such as neovascular age-related macular degeneration, retinopathy of prematurity, and proliferative vitreoretinopathy. In addition, PDGFs and PDGFRs are also important players in ocular diseases involving the degeneration of retinal neuronal and vascular cells, such as glaucoma and retinitis pigmentosa. Due to their critical roles in the pathogenesis of many blinding ocular diseases, the PDGFs and PDGFRs have been considered as important target molecules for the treatment of eye diseases. PDGF-C and PDGF-D are relatively new members of the PDGF family and are potent angiogenic and survival factors. Recent studies have demonstrated their important roles in different types of eye diseases. Thus, modulating PDGF-C and PDGF-D activities may have therapeutic values for the treatment of ocular neovascular and degenerative diseases. This review mainly summarizes the recent advances on PDGF-C and PDGF-D biology in relationship to some major ocular diseases.
Insights
Platelet-derived growth factors (PDGFs) and their receptors are key in eye diseases. Targeting newer PDGF-C and PDGF-D may offer new treatments for vision loss.
Area of Science:
- Ophthalmology
- Molecular Biology
- Cell Biology
Background:
- Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are crucial for ocular tissue regulation.
- Dysregulation of PDGFs/PDGFRs is implicated in major blinding eye conditions, including neovascular and degenerative diseases.
- Established roles in conditions like age-related macular degeneration and glaucoma highlight their significance.
Purpose of the Study:
- To review recent advances in PDGF-C and PDGF-D biology.
- To explore their specific roles in major ocular diseases.
- To assess their therapeutic potential for eye conditions.
Main Methods:
- Literature review of recent studies on PDGF-C and PDGF-D.
- Analysis of their biological functions in ocular tissues.
- Correlation of their activity with pathogenesis of eye diseases.
Main Results:
- PDGF-C and PDGF-D are potent angiogenic and survival factors.
- These factors play significant roles in various ocular diseases, including neovascular and degenerative types.
- Evidence suggests their involvement in conditions like glaucoma and retinopathy of prematurity.
Conclusions:
- PDGF-C and PDGF-D are critical players in the pathogenesis of blinding ocular diseases.
- Modulating PDGF-C and PDGF-D offers promising therapeutic strategies for treating eye neovascular and degenerative disorders.
- Targeting these specific PDGFs represents a potential avenue for novel eye disease treatments.
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