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2-methoxyethylacrylate modified polyurethane membrane and its blood compatibility.
1College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China.
Progress in Biophysics and Molecular Biology
|October 29, 2017
Summary
Grafting 2-methoxyethylacrylate (MEA) onto polyurethane (PU) membranes significantly enhances their hydrophilicity and blood compatibility. This modification improves material performance for biomedical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Modification
Background:
- Polyurethane (PU) membranes are widely used in biomedical devices.
- Improving the hemocompatibility of PU is crucial for reducing adverse clinical outcomes.
- Surface modification offers a promising strategy to enhance PU biocompatibility.
Purpose of the Study:
- To graft 2-methoxyethylacrylate (MEA) onto PU membranes.
- To evaluate the effect of MEA grafting on PU membrane hydrophilicity.
- To assess the blood compatibility of the modified PU membranes.
Main Methods:
- Surface grafting of MEA onto PU membranes via Michael addition.
- Characterization using Fourier Transform Infrared Spectroscopy (FTIR) and X-ray Photoelectron Spectroscopy (XPS).
- Evaluation of hydrophilicity via water contact angle measurements.
- Comprehensive blood compatibility testing (protein adsorption, platelet adhesion, hemolysis, coagulation times).
Main Results:
- Successful grafting of MEA onto the PU membrane surface was confirmed by FTIR and XPS.
- The water contact angle of the modified PU membrane decreased significantly from 86° to 48°, indicating enhanced hydrophilicity.
- Modified PU membranes exhibited improved blood compatibility, with reduced protein adsorption and platelet adhesion, and no hemolysis.
- Coagulation tests (plasma recalcification time, PT, APTT, TT) showed enhanced hemocompatibility.
Conclusions:
- MEA grafting is an effective method to improve the hydrophilicity of PU membranes.
- The enhanced hydrophilicity directly contributes to the improved blood compatibility of the modified PU membranes.
- MEA-grafted PU membranes show great potential for biomedical applications requiring excellent hemocompatibility.
