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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

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Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Nursing Management01:30

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

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Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Management of Allergic Rhinitis: A Review for the Community Pharmacist.

J Russell May1, William K Dolen2

  • 1University of Georgia College of Pharmacy, Augusta, Georgia.

Clinical Therapeutics
|October 29, 2017
PubMed
Summary

Intranasal corticosteroids like fluticasone propionate are effective for allergic rhinitis management. Combination therapy with oral antihistamines offers comparable efficacy to intranasal corticosteroids alone.

Keywords:
allergic rhinitisantihistaminescommunity pharmacycorticosteroidspharmacists

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Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Allergic rhinitis significantly impacts quality of life for millions.
  • Management strategies include allergen avoidance, pharmacotherapy, and immunotherapy.
  • Key pharmacologic options include oral/intranasal antihistamines and intranasal corticosteroids.

Purpose of the Study:

  • Compare efficacy and tolerability of intranasal corticosteroids versus second-generation oral antihistamines for allergic rhinitis.
  • Review combination therapy of fluticasone propionate with oral antihistamines.

Main Methods:

  • Selected clinical trials comparing fluticasone propionate with cetirizine, loratadine, or montelukast.
  • Included studies evaluating combination therapy of fluticasone propionate and oral antihistamines.

Main Results:

  • Fluticasone propionate showed equal or greater efficacy than cetirizine in reducing nasal symptoms.
  • Combination therapy with fluticasone propionate and loratadine demonstrated efficacy comparable to intranasal corticosteroid monotherapy.

Conclusions:

  • Pharmacotherapy for allergic rhinitis is individualized based on symptom severity and patient factors.
  • Community pharmacists play a crucial role in patient management and treatment selection.
  • Guidelines recommend intranasal corticosteroids as first-line for moderate to severe allergic rhinitis.