Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

34.0K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
34.0K
Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

15.0K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
15.0K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

32
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
32
Hypersensitivities01:30

Hypersensitivities

7.8K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.8K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

32
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
32
Decreased Body Temperature01:29

Decreased Body Temperature

1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practical Tortuosity Index Is Associated with Complete Recanalization in Distal M2 Thrombectomy: The D-MOTIVE Study.

AJNR. American journal of neuroradiology·2026
Same author

Automatic framework for PD-L1 expression evaluation in Latino patients with non-small cell lung cancer.

Journal of pathology informatics·2026
Same author

The TASK-1 and TASK-3 activator JG-C3-98 attenuates cold and mechanical responses in primary somatosensory neurons.

Frontiers in pharmacology·2026
Same author

Adjuvant therapy in biliary tract tumors: how will immunotherapy fit in the future?

Expert review of gastroenterology & hepatology·2026
Same author

Cdk5 modulates orofacial pain through P2X2/3 purinergic receptor-mediated signaling in trigeminal neurons.

Frontiers in pharmacology·2026
Same author

A retrospective review of phencyclidine in hair samples of subjects from the United States workplace drug testing population.

Journal of analytical toxicology·2026

Related Experiment Video

Updated: Feb 19, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.7K

IKD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity.

Alejandro González1, Gaspar Herrera2, Gonzalo Ugarte1

  • 1Departamento de Biología, Facultad de Química y Biología, and Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Santiago de Chile, Alameda L. Bdo. O'Higgins 3363, 9160000, Santiago, Chile.

Advances in Experimental Medicine and Biology
|October 29, 2017
PubMed
Summary

The balance between TRPM8 and Kv1.1-1.2 channels regulates cold sensitivity in sensory neurons. This balance is crucial for normal cold sensation and can be altered by nerve damage.

Keywords:
4-APCold hypersensitivityCold thermotransductionKv1 channelsPrimary sensory neuronsTRPM8α-DTx

More Related Videos

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.3K
Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

8.1K

Related Experiment Videos

Last Updated: Feb 19, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
08:35

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

Published on: March 17, 2015

15.7K
Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

15.3K
Novel Assay for Cold Nociception in Drosophila Larvae
06:52

Novel Assay for Cold Nociception in Drosophila Larvae

Published on: April 3, 2017

8.1K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Sensory Physiology

Background:

  • Cold sensitivity in primary sensory neurons relies on TRPM8 channels and Kv1.1-1.2 potassium channels.
  • Kv1.1-1.2 channels provide an excitability brake current (IKD), reducing neuronal excitability and raising the thermal threshold.

Purpose of the Study:

  • To investigate the biophysical properties of the IKD current in primary sensory neurons.
  • To elucidate the role of IKD in cold thermotransduction.
  • To examine the impact of peripheral nerve damage on cold sensitivity via IKD.

Main Methods:

  • Electrophysiological recordings in primary sensory neurons.
  • Analysis of ion channel function and expression.
  • Investigation of cold-induced neuronal responses.

Main Results:

  • The functional balance between TRPM8 and Kv1.1-1.2 channels dictates cold sensitivity.
  • IKD current plays a central role in regulating cold thermotransduction.
  • Peripheral nerve damage can alter cold sensitivity by affecting this channel balance.

Conclusions:

  • The interplay between TRPM8 and Kv1.1-1.2 channels is fundamental for precise cold sensation.
  • Dysregulation of IKD contributes to altered cold sensitivity following nerve injury.